Chronic multifocal non-bacterial osteomyelitis in hypophosphatasia mimicking malignancy
نویسندگان
چکیده
منابع مشابه
Chronic multifocal non-bacterial osteomyelitis in hypophosphatasia mimicking malignancy
BACKGROUND Hypophosphatasia (HP) is characterized by a genetic defect in the tissue-nonspecific alkaline phosphatase (TNSALP) gene and predominantly an autosomal recessive trait. HP patients suffer from reduced bone mineralization. Biochemically, elevated concentrations of substrates of TNSALP, including pyridoxal-5'-phosphate and inorganic pyrophosphate occur in serum, tissues and urine. The l...
متن کاملUnifocal and multifocal chronic non-bacterial osteomyelitis (CNO) in children
Methods We retrospectively evaluated patients with sterile bone inflammation, lasting longer than 6 month, referred to two tertiary care pediatric rheumatology units. Information on family history, clinical features at disease onset and course, laboratory and outcome were collected. A comparison between unifocal (UF-CNO) and multifocal course (MF-CNO), based on bone scintiscan result, was perfo...
متن کاملChronic Recurrent Multifocal Osteomyelitis Mimicking Osteosarcoma
We report a case of an adolescent female who had an initial outside clinical and imaging presentation that was considered highly suspicious for metastatic osteosarcoma. Extensive evaluation led to the diagnosis of chronic recurrent multifocal osteomyelitis. If this etiology had been considered earlier in the patient's clinical course, her diagnostic evaluation may have been less involved and tr...
متن کاملChronic Recurrent Multifocal Osteomyelitis in a 9-year-old Boy
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare aseptic, auto-inflammatory bone disorder. CRMO presents with bone pain with or without fever. The diagnosis of CRMO is a diagnosis of exclusion and should be included in the differential diagnosis of chronic inflammatory bone lesions in children. Cultures of the bone are typically sterile, antibiotic therapy does not result in clinic...
متن کاملBone scintigraphy in diagnosing chronic recurrent multifocal osteomyelitis
A 10-year-old boy was referred to us for evaluation of FUO accompanied with bone pain in both calves. Three hours after intravenous injection of 13 mCi of 99mTc-MDP, whole body scan in multiple spot views was performed. The scan showed symmetrical areas of diffusely increased tracer uptake in multiple long bones. Histopathologic evaluation confirmed osteosclrosis and fibrotic changes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Pediatrics
سال: 2007
ISSN: 1471-2431
DOI: 10.1186/1471-2431-7-3